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I am getting the following error when trying to open PC*MILER 21.

If I click ok, the application opens, but then I get the following error. What can I do?

You will need to adjust your display settings to either 16-bit or 32-bit colors. Any other settings are not supported.

Right click on your desktop.
Go to Properties.
Go to the "Settings" tab.
On the Color quality dropdown, choose either 16-bit or 32-bit.